PUF60

This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Description

poly-U binding splicing factor 60KDa

Protein family

Mapped to UniProt SWISS-PROT, Potentially secreted proteins

Chromosome

8:q24.3 (144898514 - 144912029)

Ensembl ID

ENSG00000179950  (ver. 71.37)

Orthologs

Mouse Puf60: ENSMUSG00000002524

Human splice variants
Mouse splice variants