CCBP2

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Description

chemokine binding protein 2

Protein family

GPCRs excl olfactory receptors, Membrane proteins predicted by MDM

Chromosome

3:p22.1 (42846244 - 42949597)

Ensembl ID

ENSG00000144648  (ver. 69.37)

Orthologs

Mouse Ccbp2: ENSMUSG00000044534

Human splice variants
Mouse splice variants