HTR2B

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Description

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Protein family

GPCRs excl olfactory receptors, Membrane proteins predicted by MDM

Chromosome

2:q37.1 (231972944 - 231989832)

Ensembl ID

ENSG00000135914  (ver. 69.37)

Orthologs

Mouse Htr2b: ENSMUSG00000026228

Human splice variants
Mouse splice variants