CCR2

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

Description

chemokine (C-C motif) receptor 2

Protein family

CD markers, GPCRs excl olfactory receptors, Membrane proteins predicted by MDM

Chromosome

3:p21.31 (46395225 - 46402419)

Ensembl ID

ENSG00000121807  (ver. 69.37)

Orthologs

-

Human splice variants