ATP6AP1

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq, Jul 2008]

Description

ATPase, H+ transporting, lysosomal accessory protein 1

Protein family

Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

X:q28 (153656978 - 153664862)

Ensembl ID

ENSG00000071553  (ver. 69.37)

Orthologs

Mouse Atp6ap1: ENSMUSG00000019087

Human splice variants
Mouse splice variants