ADRA2A

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Description

adrenoceptor alpha 2A

Protein family

G-protein coupled receptors, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

10:q25.2 (112836790 - 112840658)

Ensembl ID

ENSG00000150594  (ver. 71.37)

Orthologs

Mouse Adra2a: ENSMUSG00000033717

Human splice variants
Mouse splice variants