LATS1

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Jul 2008]

Description

LATS, large tumor suppressor, homolog 1 (Drosophila)

Protein family

Enzymes, Kinases

Chromosome

6:q25.1 (149979289 - 150039392)

Ensembl ID

ENSG00000131023  (ver. 69.37)

Orthologs

Mouse Lats1: ENSMUSG00000040021

Human splice variants
Mouse splice variants