SENP5

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]). [supplied by OMIM, Jun 2009]

Description

SUMO1/sentrin specific peptidase 5

Protein family

Enzymes, Peptidases

Chromosome

3:q29 (196594727 - 196661585)

Ensembl ID

ENSG00000119231  (ver. 69.37)

Orthologs

Mouse Senp5: ENSMUSG00000022772

Human splice variants
Mouse splice variants