HDAC6

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Description

histone deacetylase 6

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

X:p11.23 (48659784 - 48683392)

Ensembl ID

ENSG00000094631  (ver. 71.37)

Orthologs

Mouse Hdac6: ENSMUSG00000031161

Human splice variants
Mouse splice variants