MAPKAPK2

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

mitogen-activated protein kinase-activated protein kinase 2

Protein family

Candidate cancer biomarkers, Enzymes, Kinases, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

1:q32.1 (206858289 - 206907628)

Ensembl ID

ENSG00000162889  (ver. 71.37)

Orthologs

Mouse Mapkapk2: ENSMUSG00000016528

Human splice variants
Mouse splice variants