CRK

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Description

v-crk sarcoma virus CT10 oncogene homolog (avian)

Protein family

SH2-domain containing proteins, SH3-domain containing proteins

Chromosome

17:p13.3 (1323983 - 1366456)

Ensembl ID

ENSG00000167193  (ver. 69.37)

Orthologs

Mouse Crk: ENSMUSG00000017776

Human splice variants
Mouse splice variants