ATRX

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Description

alpha thalassemia/mental retardation syndrome X-linked

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

X:q21.1 (76760356 - 77041702)

Ensembl ID

ENSG00000085224  (ver. 71.37)

Orthologs

Mouse Atrx: ENSMUSG00000031229

Human splice variants
Mouse splice variants