ARHGEF12

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Description

Rho guanine nucleotide exchange factor (GEF) 12

Protein family

-

Chromosome

11:q23.3 (120207787 - 120360645)

Ensembl ID

ENSG00000196914  (ver. 69.37)

Orthologs

Mouse Arhgef12: ENSMUSG00000059495

Human splice variants
Mouse splice variants