ATP6V1B2

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Description

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

Protein family

Transporters

Chromosome

8:p21.3 (20054878 - 20084330)

Ensembl ID

ENSG00000147416  (ver. 69.37)

Orthologs

Mouse Atp6v1b2: ENSMUSG00000006273

Human splice variants
Mouse splice variants