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Protein structure
IL17RC
Interleukin 17 receptor CIL17-RL
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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| Novus Biologicals |  AF2270 |
3 references | Polyclonal |
WB
FC
BN
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| R&D Systems | AF2270 |
3 references | Polyclonal |
WB
FC
BN
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| Proteintech Group | 15648-1-AP |
2 references | Polyclonal |
WB
EL
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| antibodies-online | ABIN2487896 |
Polyclonal |
WB
ICC
IHC
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| Affinity Biosciences | DF4708 |
Polyclonal |
WB
EL
ICC
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