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Protein structure
OSM
Oncostatin MMGC20461
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Top validated antibodies |
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| R&D Systems |  AF-495-NA |
8 references | Polyclonal |
WB
IHC
BN
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| Novus Biologicals | AF-495-NA |
8 references | Polyclonal |
WB
IHC
BN
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| OriGene | PP1060P1 |
Polyclonal |
WB
EL
IHC
FA
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| Proteintech Group | 27792-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN2492044 |
Polyclonal |
WB
EL
ICC
IHC
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