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Protein structure
F7
Coagulation factor VIIThis gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Top validated antibodies |
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| R&D Systems |  AF2338 |
3 references | Polyclonal |
WB
ICC
IP
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| Novus Biologicals | AF2338 |
3 references | Polyclonal |
WB
ICC
IP
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| Proteintech Group | 23058-1-AP |
1 references | Polyclonal |
WB
EL
ICC
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| LSBio | LS-C404335 |
Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN441425 |
1 references | Polyclonal |
WB
IHC
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