CISH

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Description

Cytokine inducible SH2 containing protein

Tissue specificity

Tissue enhanced (liver)

Subcell location

Microtubules, Cytokinetic bridge

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

3 (50606489 - 50611774)

Ensembl ID

ENSG00000114737  (ver. 103.38)

Orthologs

Mouse Cish: ENSMUSG00000032578

UniProt

Q9NSE2

neXtProt

NX_Q9NSE2

Human splice variants
Mouse splice variants

Protein structure