MUC4

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]

Description

Mucin 4, cell surface associated

Tissue specificity

Tissue enhanced (esophagus, intestine, prostate, vagina)

Predicted location

Membrane, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (195746765 - 195811973)

Ensembl ID

ENSG00000145113  (ver. 103.38)

Orthologs

Mouse Muc4: ENSMUSG00000118672

UniProt

Q99102

neXtProt

NX_Q99102

Human splice variants
Mouse splice variants

Protein structure