Ab116451

antibody from Aladdin Scientific Corporation

Targeting: MUC4

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab116451

Provider

Aladdin Scientific Corporation

Product name

Recombinant MUC4 Antibody

Antibody type

Recombinant

Description

Rabbit anti Human MUC4 Antibody, Recombinant (R02-7G1), could be used for WB and so on.Application:WB: 1/500 – 1/1000Protein FunctionMay play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 1564-1673


Antibody clone number

R02-7G1

Vial size

100μl,10μl,1ml,50μl

Concentration

0,65 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.