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- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Immunohistochemistry [1]
- Blocking/Neutralizing [1]
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- Product number
- AF537 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal CX3CL1/Fractalkine Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects rat CX3CL1/Fractalkine in ELISAs and Western blots. Neutralizes the biological activity of recombinant human CX3CL1 and recombinant mouse CX3CL1 with similar effectiveness.
- Reactivity
- Rat
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.
Noradrenaline induces CX3CL1 production and release by neurons.
Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats.
Selective activation of microglia facilitates synaptic strength.
Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons.
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.
Castro-Sánchez S, García-Yagüe ÁJ, López-Royo T, Casarejos M, Lanciego JL, Lastres-Becker I
Glia 2018 Aug;66(8):1752-1762
Glia 2018 Aug;66(8):1752-1762
Noradrenaline induces CX3CL1 production and release by neurons.
Madrigal JL, Caso JR, García-Bueno B, Gutiérrez IL, Leza JC
Neuropharmacology 2017 Mar 1;114:146-155
Neuropharmacology 2017 Mar 1;114:146-155
Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats.
Yeh PT, Huang HW, Yang CM, Yang WS, Yang CH
PloS one 2016;11(1):e0146438
PloS one 2016;11(1):e0146438
Selective activation of microglia facilitates synaptic strength.
Clark AK, Gruber-Schoffnegger D, Drdla-Schutting R, Gerhold KJ, Malcangio M, Sandkühler J
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar 18;35(11):4552-70
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar 18;35(11):4552-70
Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons.
Cook A, Hippensteel R, Shimizu S, Nicolai J, Fatatis A, Meucci O
The Journal of biological chemistry 2010 Apr 2;285(14):10563-71
The Journal of biological chemistry 2010 Apr 2;285(14):10563-71
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.
Clark AK, Yip PK, Grist J, Gentry C, Staniland AA, Marchand F, Dehvari M, Wotherspoon G, Winter J, Ullah J, Bevan S, Malcangio M
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 19;104(25):10655-60
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 19;104(25):10655-60
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- CX3CL1/Fractalkine in Mouse Brain. CX3CL1/Fractalkine in Mouse Brain.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Rat CX3CL1/Fractalkine Antibody. Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Rat CX3CL1/Fractalkine Antibody.
