CX3CL1

This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]

Description

C-X3-C motif chemokine ligand 1

Tissue specificity

Tissue enhanced (breast)

Subcell location

Plasma membrane

Predicted location

Membrane, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

16 (57372477 - 57385044)

Ensembl ID

ENSG00000006210  (ver. 103.38)

Orthologs

Mouse Cx3cl1: ENSMUSG00000031778

UniProt

P78423

neXtProt

NX_P78423

Human splice variants
Mouse splice variants

Protein structure