Tissue expression
Cell line expression
Protein structure
MDH1
Malate dehydrogenase 1This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
Top validated antibodies |
|||||
Proteintech Group | 15904-1-AP | 12 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | 15904-1-AP | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
||
NovoPro Bioscience Inc. | 112568 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
||
GeneTex | GTX40570 | 1 references | Polyclonal |
WB
EL
IP
IHC |
|
Wuhan Fine Biotech Co., Ltd. | FNab05073 | Polyclonal |
WB
EL
ICC
IP
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider