LRWD1

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Description

Leucine rich repeats and WD repeat domain containing 1

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Nucleoli, Nucleoli rim, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (102464956 - 102473168)

Ensembl ID

ENSG00000161036  (ver. 103.38)

Orthologs

Mouse Lrwd1: ENSMUSG00000029703

UniProt

Q9UFC0

neXtProt

NX_Q9UFC0

Human splice variants
Mouse splice variants

Protein structure