DNTT

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Description

DNA nucleotidylexotransferase

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

10 (96304409 - 96338564)

Ensembl ID

ENSG00000107447  (ver. 103.38)

Orthologs

Mouse Dntt: ENSMUSG00000025014

UniProt

P04053

neXtProt

NX_P04053

Human splice variants
Mouse splice variants

Protein structure