CPE

This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]

Description

Carboxypeptidase E

Tissue specificity

Tissue enhanced (brain, retina)

Subcell location

Nucleoplasm, Vesicles, Centrosome

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (165361194 - 165498547)

Ensembl ID

ENSG00000109472  (ver. 103.38)

Orthologs

Mouse Cpe: ENSMUSG00000037852

UniProt

P16870

neXtProt

NX_P16870

Human splice variants
Mouse splice variants

Protein structure