Explore
Validate
Learn
Western blot
Immunocytochemistry
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [4]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN151774 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-ATR antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 2B5
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells.
Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin.
Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes.
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse.
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.
Regulation of CHK2 by DNA-dependent protein kinase.
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.
Cell cycle checkpoint signaling through the ATM and ATR kinases.
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.
Haro KJ, Sheth A, Scheinberg DA
PloS one 2012;7(11):e48841
PloS one 2012;7(11):e48841
Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin.
Oku T, Nakano M, Kaneko Y, Ando Y, Kenmotsu H, Itoh S, Tsuiji M, Seyama Y, Toyoshima S, Tsuji T
The Journal of biological chemistry 2012 Dec 14;287(51):42910-20
The Journal of biological chemistry 2012 Dec 14;287(51):42910-20
Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
Ha K, Fiskus W, Rao R, Balusu R, Venkannagari S, Nalabothula NR, Bhalla KN
Molecular cancer therapeutics 2011 Jul;10(7):1194-206
Molecular cancer therapeutics 2011 Jul;10(7):1194-206
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Chen Y, Chen CF, Riley DJ, Chen PL
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.
Zuco V, Benedetti V, Zunino F
Cancer letters 2010 Jun 28;292(2):186-96
Cancer letters 2010 Jun 28;292(2):186-96
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Cui B, Johnson SP, Bullock N, Ali-Osman F, Bigner DD, Friedman HS
Molecular pharmacology 2009 Jun;75(6):1356-63
Molecular pharmacology 2009 Jun;75(6):1356-63
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.
Kulkarni A, Das KC
American journal of physiology. Lung cellular and molecular physiology 2008 May;294(5):L998-L1006
American journal of physiology. Lung cellular and molecular physiology 2008 May;294(5):L998-L1006
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Liu X, Matsuda A, Plunkett W
Molecular cancer therapeutics 2008 Jan;7(1):133-42
Molecular cancer therapeutics 2008 Jan;7(1):133-42
Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes.
Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, Mizutani S
Cancer science 2008 Aug;99(8):1539-45
Cancer science 2008 Aug;99(8):1539-45
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
Wu X, Shell SM, Liu Y, Zou Y
Oncogene 2007 Feb 1;26(5):757-64
Oncogene 2007 Feb 1;26(5):757-64
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse.
Manthey KC, Opiyo S, Glanzer JG, Dimitrova D, Elliott J, Oakley GG
Journal of cell science 2007 Dec 1;120(Pt 23):4221-9
Journal of cell science 2007 Dec 1;120(Pt 23):4221-9
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Tyagi A, Singh RP, Agarwal C, Agarwal R
Carcinogenesis 2006 Nov;27(11):2269-80
Carcinogenesis 2006 Nov;27(11):2269-80
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y
Journal of cell science 2006 Nov 15;119(Pt 22):4644-9
Journal of cell science 2006 Nov 15;119(Pt 22):4644-9
Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.
Wu X, Shell SM, Yang Z, Zou Y
Cancer research 2006 Mar 15;66(6):2997-3005
Cancer research 2006 Mar 15;66(6):2997-3005
Regulation of CHK2 by DNA-dependent protein kinase.
Li J, Stern DF
The Journal of biological chemistry 2005 Mar 25;280(12):12041-50
The Journal of biological chemistry 2005 Mar 25;280(12):12041-50
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Gibson SL, Bindra RS, Glazer PM
Cancer research 2005 Dec 1;65(23):10734-41
Cancer research 2005 Dec 1;65(23):10734-41
Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.
Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH
The Journal of biological chemistry 2005 Apr 22;280(16):15773-85
The Journal of biological chemistry 2005 Apr 22;280(16):15773-85
Cell cycle checkpoint signaling through the ATM and ATR kinases.
Abraham RT
Genes & development 2001 Sep 1;15(17):2177-96
Genes & development 2001 Sep 1;15(17):2177-96
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.
Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY
Proceedings of the National Academy of Sciences of the United States of America 2001 Nov 6;98(23):13102-7
Proceedings of the National Academy of Sciences of the United States of America 2001 Nov 6;98(23):13102-7
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
