PLAU

gene product
UPA, URK
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
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527 antibodies from 34 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
Abgent
5 antibodies
Novus Biologicals
21 antibodies
Abnova Corporation
16 antibodies
NSJ Bioreagents
4 antibodies
Invitrogen Antibodies
11 antibodies
antibodies-online
111 antibodies
NovoPro Bioscience Inc.
5 antibodies
R&D Systems
4 antibodies
Aviva Systems Biology
7 antibodies
OriGene
8 antibodies
LifeSpan BioSciences, Inc.
103 antibodies
Proteintech Group
1 antibody
YO Proteins AB
4 antibodies
GeneTex
29 antibodies
Acris Antibodies GmbH
24 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
2 antibodies
BioLegend
5 antibodies
RabMAbs
5 antibodies
MyBioSource
35 antibodies
Biorbyt
8 antibodies
Creative Biolabs
4 antibodies
Everest Biotech
1 antibody
United States Biological
62 antibodies
GenWay
12 antibodies
Arigo
1 antibody
Abbiotec
1 antibody
Molecular Innovations
14 antibodies
EMD Millipore
3 antibodies
St John's Laboratory
3 antibodies
Sigma-Aldrich
3 antibodies
Sino Biological Inc.
1 antibody
Creative Biomart
1 antibody