Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- NBP1-40894-0.1mg - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-40894-0.1mg, RRID:AB_10005018
- Product name
- Rat Monoclonal P2X7/P2RX7 Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified. This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
- Reactivity
- Mouse
- Host
- Rat
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: P2X7/P2RX7 Antibody (Hano43) [NBP1-40894] - Flow Cytometry: P2X7/P2RX7 Antibody (Hano43) [Alexa Fluor® 647] [NBP1-40894AF647] - Mouse dendritic cells (BMDCs) stained for CD11c and P2X7. Image from verified customer review. Image using the Alexa Fluor 647 form of this antibody.