Tissue expression
Cell line expression
Protein structure
P2RX7
Purinergic receptor P2X 7MGC20089, P2X7
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
Top validated antibodies |
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Proteintech Group | ![]() |
17 references | Polyclonal |
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antibodies-online | ![]() |
Monoclonal |
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GeneTex | ![]() |
1 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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Novus Biologicals | ![]() |
2 references | Polyclonal |
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