MDM4

gene product
MDMX
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
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183 antibodies from 20 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Bethyl Laboratories, Inc.
5 antibodies
Novus Biologicals
10 antibodies
antibodies-online
68 antibodies
Abnova Corporation
8 antibodies
GeneTex
4 antibodies
Thermo Fisher Scientific Pierce
5 antibodies
Acris Antibodies GmbH
2 antibodies
LifeSpan BioSciences, Inc.
32 antibodies
Aviva Systems Biology
5 antibodies
Creative Biomart
15 antibodies
EMD Millipore
2 antibodies
Proteintech Group
1 antibody
RayBiotech, Inc.
2 antibodies
Atlas Antibodies
1 antibody
Abbiotec
1 antibody
Abiocode, Inc.
1 antibody
ChromoTek
1 antibody
United States Biological
13 antibodies
Sigma-Aldrich
5 antibodies
GenWay
2 antibodies