MDM4

gene product
HDMX, MDMX
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
More gene data

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324 antibodies from 28 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
Bethyl Laboratories, Inc.
9 antibodies
Novus Biologicals
10 antibodies
antibodies-online
114 antibodies
OriGene
17 antibodies
Abnova Corporation
9 antibodies
GeneTex
4 antibodies
Acris Antibodies GmbH
4 antibodies
Biorbyt
9 antibodies
Invitrogen Antibodies
5 antibodies
LifeSpan BioSciences, Inc.
49 antibodies
Aviva Systems Biology
5 antibodies
Abgent
6 antibodies
Proteintech Group
1 antibody
EMD Millipore
2 antibodies
Creative Biolabs
3 antibodies
MyBioSource
10 antibodies
Creative Diagnostics
7 antibodies
RayBiotech, Inc.
2 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
2 antibodies
Abbiotec
1 antibody
Abiocode, Inc.
1 antibody
Bioworld Technology, Inc
1 antibody
ChromoTek
1 antibody
United States Biological
32 antibodies
Sigma-Aldrich
5 antibodies
GenWay
2 antibodies