Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 17914-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17914-1-AP, RRID:AB_2143683
- Product name
- MDMX antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MDMX antibody (Cat. #17914-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors.
Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.
EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis.
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.
FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.
Si D, Luo H, Zhang X, Yang K, Wen H, Li W, Liu J
Bioorganic chemistry 2021 Oct;115:105268
Bioorganic chemistry 2021 Oct;115:105268
Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.
Kim H, Shin JY, Jo A, Kim JH, Park S, Choi JY, Kang HC, Dawson VL, Dawson TM, Shin JH, Lee Y
Brain : a journal of neurology 2021 Dec 31;144(12):3674-3691
Brain : a journal of neurology 2021 Dec 31;144(12):3674-3691
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.
Yan H, Chen X, Li Y, Fan L, Tai Y, Zhou Y, Chen Y, Qi X, Huang R, Ren J
American journal of cancer research 2019;9(2):312-329
American journal of cancer research 2019;9(2):312-329
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Wu Z, Chen D, Wang K, Cao C, Xu X
Frontiers in oncology 2019;9:1260
Frontiers in oncology 2019;9:1260
Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.
Gao C, Xiao G, Piersigilli A, Gou J, Ogunwobi O, Bargonetti J
Breast cancer research : BCR 2019 Jan 14;21(1):5
Breast cancer research : BCR 2019 Jan 14;21(1):5
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Sun Y, Liu W, Wang C, Meng Q, Liu Z, Huo X, Yang X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.
Fan C, Wang X
Cell cycle (Georgetown, Tex.) 2017 Apr 3;16(7):660-664
Cell cycle (Georgetown, Tex.) 2017 Apr 3;16(7):660-664
EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis.
Smonskey M, Lasorsa E, Rosario S, Kirk JS, Hernandez-Ilizaliturri FJ, Ellis L
Oncoscience 2016;3(1):21-30
Oncoscience 2016;3(1):21-30
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Jiang YQ, Xu XP, Guo QM, Xu XC, Liu QY, An SH, Xu JL, Su F, Tai JB
Genetics and molecular research : GMR 2016 Sep 2;15(3)
Genetics and molecular research : GMR 2016 Sep 2;15(3)
Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.
Wu W, Xu C, Ling X, Fan C, Buckley BP, Chernov MV, Ellis L, Li F, Muñoz IG, Wang X
Cell death & disease 2015 Dec 31;6:e2035
Cell death & disease 2015 Dec 31;6:e2035
FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.
Ling X, Xu C, Fan C, Zhong K, Li F, Wang X
Cancer research 2014 Dec 15;74(24):7487-97
Cancer research 2014 Dec 15;74(24):7487-97
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MDMX antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MDMX. This antibody recognizes human,mouse,rat antigen. The MDMX antibody has been validated for the following applications: ELISA, WB analysis.