BS60545

antibody from Bioworld Technology, Inc
Targeting: CLEC6A CLECSF10, dectin-2
Provider product page for BS60545

Antibody data

Product number
BS60545 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CLEC6A polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CLEC6A
Description
Together, Dectin-1 and Dectin-2 make up the unique subfamily of dendritic cell-associated C-type lectins. Dectin-2 is expressed on antigen-presenting cells, where it interacts with its putative ligands on T cells. That interaction may deliver co-stimulatory signals in naive T cells. Dectin-2 expression is upregulated during monocyte activation and maturation at inflammatory lesions. Broadband UV-B upregulates Dectin-2 expression in Langerhans cells by activating the Dectin-2 gene promoter, suggesting that this protein plays a crucial role in the mediation of UV-induced immunosuppression. In cattle, Dectin-2 expressed by dendritic cells may also play a role in the recognition of invading antigens in lymph nodes. Dectin-2 functions as a pattern recognition receptor for fungi that activates signaling through FcR? to induce innate immune responses.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CLEC6A protein structure - BS60545 shown in red.