CLEC6A

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Description

C-type lectin domain containing 6A

Tissue specificity

Tissue enhanced (lung, lymphoid tissue)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

12 (8455962 - 8478330)

Ensembl ID

ENSG00000205846  (ver. 103.38)

Orthologs

Mouse Clec4n: ENSMUSG00000023349

UniProt

Q6EIG7

neXtProt

NX_Q6EIG7

Human splice variants
Mouse splice variants

Protein structure