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- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Western blot [1]
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- Product number
- PAB3527 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB3527, RRID:AB_1578711
- Product name
- PHLPP1 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of PHLPP1.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references The phosphatase PHLPP controls the cellular levels of protein kinase C.
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Brognard J, Newton AC
The Journal of biological chemistry 2008 Mar 7;283(10):6300-11
The Journal of biological chemistry 2008 Mar 7;283(10):6300-11
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J, Sierecki E, Gao T, Newton AC
Molecular cell 2007 Mar 23;25(6):917-31
Molecular cell 2007 Mar 23;25(6):917-31
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC
Molecular cell 2005 Apr 1;18(1):13-24
Molecular cell 2005 Apr 1;18(1):13-24
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Supportive validation
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- Abnova Corporation (provider)
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- Experimental details
- Western blot analysis of PHLPP1 polyclonal antibody (Cat # PAB3527) in K-562 cell line lysates (35 ug/lane). PHLPP1 (arrow) was detected using the purified polyclonal antibody (1:1000 dilution).
