ABIN1449987

antibody from antibodies-online

Targeting: PHLPP1 KIAA0606, PHLPP, PLEKHE1, PPM3A, SCOP

Western blot (Supportive data in Antibodypedia)

ELISA (Recommended by provider)

Antibody Data

Product number

ABIN1449987

Provider

antibodies-online

Product name

anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1) (N-Term) antibody

Antibody type

Polyclonal

Antigen

Other

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

0.1 mg

References

Submitted references

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.

Andreozzi F, Procopio C, Greco A, Mannino GC, Miele C, Raciti GA, Iadicicco C, Beguinot F, Pontiroli AE, Hribal ML, Folli F, Sesti G
Diabetologia 2011 Jul;54(7):1879-87

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PHLiPPing the switch on Akt and protein kinase C signaling.

Brognard J, Newton AC
Trends in endocrinology and metabolism: TEM 2008 Aug;19(6):223-30

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.

Brognard J, Sierecki E, Gao T, Newton AC
Molecular cell 2007 Mar 23;25(6):917-31

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.

Gao T, Furnari F, Newton AC
Molecular cell 2005 Apr 1;18(1):13-24

Western blot

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

Western blot analysis of PHLPP1 in SW480 cell lysate with PHLPP1 antibody Cat.-No AP55483PU-N at (A) 1 and (B) 2 ?g/ml.