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Western blot
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 313802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#313802, RRID:AB_345310
- Product name
- LEAF™ purified anti-human CD218a (IL-18Rá) [H44]
- Antibody type
- Monoclonal
- Antigen
- Human NK cell line NK0 constitutively expressing IL-18 receptors
- Description
- IL-18 receptor is composed of an α and a β subunit that combine to form a high affinity receptor for IL-18. IL-18 receptor α chain, also known as CDw218a, is a 75-80 kD type I transmembrane protein. It is expressed on NK cells, neutrophils, endothelial cells, and subsets of T and B cells. The expression of CDw218a on lymphocytes is upregulated after activation. The interaction of IL-18 and IL-18 receptor has been reported to be implicated in promotion of Th1 cytokine production and atherogenesis. The H44 antibody is specific for IL-18 receptor α chain and has been reported to block IL-18 binding to the receptor and to be useful for the identification of IL-18 receptor by flow cytometry and IHC.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood lymphocytes stained with LEAF™ purified H44, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated
