IL18R1

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Description

Interleukin 18 receptor 1

Tissue specificity

Tissue enhanced (lung, lymphoid tissue)

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (102311529 - 102398777)

Ensembl ID

ENSG00000115604  (ver. 103.38)

Orthologs

Mouse Il18r1: ENSMUSG00000026070

UniProt

Q13478

neXtProt

NX_Q13478

Human splice variants
Mouse splice variants

Protein structure