H4-16

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]

Description

H4 histone 16

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

12 (14767999 - 14771131)

Ensembl ID

ENSG00000197837  (ver. 103.38)

Orthologs

Mouse H4c12: ENSMUSG00000064288

UniProt

P62805

neXtProt

NX_P62805

Human splice variants
Mouse splice variants

Protein structure