CPBT-30856GH

antibody from Creative Diagnostics

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CPBT-30856GH

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#CPBT-30856GH, RRID:AB_2364887

Product name

Rabbit Anti-Human CD274 Polyclonal Antibody

Antibody type

Polyclonal

Description

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Concentration

Lot specific

Storage

Store at -20°C, and avoid repeat freeze-thaw cycles.