CD274

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Description

CD274 molecule

Tissue specificity

Tissue enhanced (lung)

Subcell location

Nucleoplasm, Plasma membrane, Actin filaments

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (5450503 - 5470566)

Ensembl ID

ENSG00000120217  (ver. 103.38)

Orthologs

Mouse Cd274: ENSMUSG00000016496

UniProt

Q9NZQ7

neXtProt

NX_Q9NZQ7

Human splice variants
Mouse splice variants

Protein structure