IL15RA

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Apr 2010]

Description

Interleukin 15 receptor subunit alpha

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Chromosome

10 (5943639 - 5978187)

Ensembl ID

ENSG00000134470  (ver. 103.38)

Orthologs

Mouse Il15ra: ENSMUSG00000023206

UniProt

Q13261

neXtProt

NX_Q13261

Human splice variants
Mouse splice variants

Protein structure