UPF2

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

Description

UPF2 regulator of nonsense mediated mRNA decay

Tissue specificity

Low tissue specificity

Subcell location

Cytosol, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (11920022 - 12043170)

Ensembl ID

ENSG00000151461  (ver. 103.38)

Orthologs

Mouse Upf2: ENSMUSG00000043241

UniProt

Q9HAU5

neXtProt

NX_Q9HAU5

Human splice variants
Mouse splice variants

Protein structure