Tissue expression
Cell line expression
Protein structure
GRID2
Glutamate ionotropic receptor delta type subunit 2GluD2, GluR-delta-2
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Top validated antibodies |
|||||
NSJ Bioreagents | ![]() |
Polyclonal |
|
||
Boster Biological Technology | ![]() |
Polyclonal |
|
||
Invitrogen Antibodies | ![]() |
Polyclonal |
|
||
St John's Laboratory | ![]() |
Polyclonal |
|
||
Antibodies.com | ![]() |
Polyclonal |
|