Antibody data
- Antibody Data
- Antigen structure
- References [62]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11565-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11565-1-AP, RRID:AB_2302808
- Product name
- STIM1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STIM1 antibody (Cat. #11565-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tibial cortex transverse transport regulates Orai1/STIM1-mediated NO release and improve the migration and proliferation of vessels via increasing osteopontin expression.
Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis.
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
STIM1 interacts with HCN4 channels to coordinate diastolic depolarization in the mouse Sinoatrial node.
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth.
Sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA)-mediated ER stress crosstalk with autophagy is involved in tris(2-chloroethyl) phosphate stress-induced cardiac fibrosis.
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.
Enhanced Orai1-mediated store-operated Ca(2+) channel/calpain signaling contributes to high glucose-induced podocyte injury.
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Transmembrane Protein Ttyh1 Maintains the Quiescence of Neural Stem Cells Through Ca(2+)/NFATc3 Signaling.
Immune Checkpoint Inhibitors Regulate K(+) Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients.
Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca(2+) Axis.
Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4(+) T-Cell Compartments.
The role of STIM1/ORAI1 channel in the analgesic effect of grain-sized moxibustion on inflammatory pain mice model.
Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca(2+) Signaling in Nasopharyngeal Carcinoma.
Deficiency of ER Ca(2+) sensor STIM1 in AgRP neurons confers protection against dietary obesity.
Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee.
A short isoform of STIM1 confers frequency-dependent synaptic enhancement.
Nitric oxide displays a biphasic effect on calcium dynamics in microglia.
Resveratrol sensitizes A549 cells to irradiation damage via suppression of store-operated calcium entry with Orai1 and STIM1 downregulation.
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.
Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis.
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.
Soluble αKlotho downregulates Orai1-mediated store-operated Ca(2+) entry via PI3K-dependent signaling.
RANK promotes colorectal cancer migration and invasion by activating the Ca(2+)-calcineurin/NFATC1-ACP5 axis.
The role of Stim1 in the progression of lupus nephritis in mice.
PD1 blockade enhances K(+) channel activity, Ca(2+) signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer.
STIM1-Ca(2+) signaling in coronary sinus cardiomyocytes contributes to interatrial conduction.
Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry.
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8(+) T cells of elderly mice.
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Nitric Oxide Critically Regulates Purkinje Neuron Dendritic Development Through a Metabotropic Glutamate Receptor Type 1-Mediated Mechanism.
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
miRNA-dependent regulation of STIM1 expression in breast cancer.
Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis.
FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis.
E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca(2+) Store Replenishment.
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.
Inhibition of stromal-interacting molecule 1-mediated store-operated Ca(2+) entry as a novel strategy for the treatment of acquired imatinib-resistant gastrointestinal stromal tumors.
Profiling calcium signals of in vitro polarized human effector CD4(+) T cells.
STIM1 and STIM2 differently regulate endogenous Ca(2+) entry and promote TGF-β-induced EMT in breast cancer cells.
Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca(2+) entry regulates disassembly of adherens junctions.
Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells.
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells.
AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons.
Expression profiling of human basophils: modulation by cytokines and secretagogues.
STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
Impairment of hepatic nuclear factor-4α binding to the Stim1 promoter contributes to high glucose-induced upregulation of STIM1 expression in glomerular mesangial cells.
High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.
Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin.
Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase.
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.
Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons.
Functional interactions among STIM1, Orai1 and TRPC1 on the activation of SOCs in HL-7702 cells.
Immunolocalization of STIM1 in the mouse brain.
Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease.
Expression of STIM1 in brain and puncta-like co-localization of STIM1 and ORAI1 upon depletion of Ca(2+) store in neurons.
Kong L, Li Y, Deng Z, Chen X, Xia Y, Shen B, Ning R, Zhang L, Yin Z
Journal of orthopaedic translation 2024 Mar;45:107-119
Journal of orthopaedic translation 2024 Mar;45:107-119
Dexamethasone upregulates macrophage PIEZO1 via SGK1, suppressing inflammation and increasing ROS and apoptosis.
Liu H, Zhou L, Wang X, Zheng Q, Zhan F, Zhou L, Dong Y, Xiong Y, Yi P, Xu G, Hua F
Biochemical pharmacology 2024 Apr;222:116050
Biochemical pharmacology 2024 Apr;222:116050
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons.
Serwach K, Nurowska E, Klukowska M, Zablocka B, Gruszczynska-Biegala J
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
Cellular and molecular life sciences : CMLS 2023 Nov 21;80(12):368
STIM1 interacts with HCN4 channels to coordinate diastolic depolarization in the mouse Sinoatrial node.
Zhang H, Graham V, Nepliouev I, Stiber JA, Rosenberg P
bioRxiv : the preprint server for biology 2023 May 3;
bioRxiv : the preprint server for biology 2023 May 3;
Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth.
Gu C, Zhang W, Yang E, Gu C, Zhang Z, Ke J, Wang X, Wu S, Li S, Wu F
Oncogenesis 2022 Sep 15;11(1):55
Oncogenesis 2022 Sep 15;11(1):55
Sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA)-mediated ER stress crosstalk with autophagy is involved in tris(2-chloroethyl) phosphate stress-induced cardiac fibrosis.
Xiong X, Zhang X, Zhang Y, Xie J, Bian Y, Yin Q, Tong R, Yu D, Pan L
Journal of inorganic biochemistry 2022 Nov;236:111972
Journal of inorganic biochemistry 2022 Nov;236:111972
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.
Hu A, Zhang JZ, Wang J, Li CC, Yuan M, Deng G, Lin ZC, Qiu ZP, Liu HY, Wang XW, Wei PC, He X, Zhao X, Qiu WW, Song BL
Cell research 2022 Mar;32(3):288-301
Cell research 2022 Mar;32(3):288-301
Enhanced Orai1-mediated store-operated Ca(2+) channel/calpain signaling contributes to high glucose-induced podocyte injury.
Tao Y, Chaudhari S, Shotorbani PY, Ding Y, Chen Z, Kasetti R, Zode G, Ma R
The Journal of biological chemistry 2022 Jun;298(6):101990
The Journal of biological chemistry 2022 Jun;298(6):101990
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Sicking M, Živná M, Bhadra P, Barešová V, Tirincsi A, Hadzibeganovic D, Hodaňová K, Vyleťal P, Sovová J, Jedličková I, Jung M, Bell T, Helms V, Bleyer AJ, Kmoch S, Cavalié A, Lang S
Life science alliance 2022 Apr;5(4)
Life science alliance 2022 Apr;5(4)
Transmembrane Protein Ttyh1 Maintains the Quiescence of Neural Stem Cells Through Ca(2+)/NFATc3 Signaling.
Cao Y, Wu HN, Cao XL, Yue KY, Han WJ, Cao ZP, Zhang YF, Gao XY, Luo C, Jiang XF, Han H, Zheng MH
Frontiers in cell and developmental biology 2021;9:779373
Frontiers in cell and developmental biology 2021;9:779373
Immune Checkpoint Inhibitors Regulate K(+) Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients.
Gawali VS, Chimote AA, Newton HS, Feria-Garzón MG, Chirra M, Janssen EM, Wise-Draper TM, Conforti L
Frontiers in pharmacology 2021;12:742862
Frontiers in pharmacology 2021;12:742862
Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca(2+) Axis.
Zhu X, Zhan Y, Gu Y, Huang Q, Wang T, Deng Z, Xie J
Frontiers in physiology 2021;12:733650
Frontiers in physiology 2021;12:733650
Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4(+) T-Cell Compartments.
Merino-Wong M, Niemeyer BA, Alansary D
Frontiers in immunology 2021;12:687242
Frontiers in immunology 2021;12:687242
The role of STIM1/ORAI1 channel in the analgesic effect of grain-sized moxibustion on inflammatory pain mice model.
Zhang CS, Zuo CY, Lv P, Zhang HX, Lin SR, Huang RZ, Shi G, Dai XQ
Life sciences 2021 Sep 1;280:119699
Life sciences 2021 Sep 1;280:119699
Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca(2+) Signaling in Nasopharyngeal Carcinoma.
Ye J, Wei J, Luo Y, Deng Y, Que T, Zhang X, Liu F, Zhang J, Luo X
Pathogens (Basel, Switzerland) 2021 Oct 3;10(10)
Pathogens (Basel, Switzerland) 2021 Oct 3;10(10)
Deficiency of ER Ca(2+) sensor STIM1 in AgRP neurons confers protection against dietary obesity.
Chen Z, Pan S, Yin K, Zhang Y, Yuan X, Wang S, Yang S, Shen Q, Tang Y, Li J, Wang Y, Lu Y, Zhang G
Cell reports 2021 Oct 19;37(3):109868
Cell reports 2021 Oct 19;37(3):109868
Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee.
Mählich D, Glasmacher A, Müller I, Oppermann J, Grevenstein D, Eysel P, Heilig J, Wirth B, Zaucke F, Niehoff A
International journal of molecular sciences 2021 Mar 17;22(6)
International journal of molecular sciences 2021 Mar 17;22(6)
A short isoform of STIM1 confers frequency-dependent synaptic enhancement.
Ramesh G, Jarzembowski L, Schwarz Y, Poth V, Konrad M, Knapp ML, Schwär G, Lauer AA, Grimm MOW, Alansary D, Bruns D, Niemeyer BA
Cell reports 2021 Mar 16;34(11):108844
Cell reports 2021 Mar 16;34(11):108844
Nitric oxide displays a biphasic effect on calcium dynamics in microglia.
Maksoud MJE, Tellios V, Xiang YY, Lu WY
Nitric oxide : biology and chemistry 2021 Mar 1;108:28-39
Nitric oxide : biology and chemistry 2021 Mar 1;108:28-39
Resveratrol sensitizes A549 cells to irradiation damage via suppression of store-operated calcium entry with Orai1 and STIM1 downregulation.
Lele W, Lei L, Liting Q
Experimental and therapeutic medicine 2021 Jun;21(6):587
Experimental and therapeutic medicine 2021 Jun;21(6):587
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Wendimu MY, Alqinyah M, Vella S, Dean P, Almutairi F, Davila-Rivera R, Rayatpisheh S, Wohlschlegel J, Moreno S, Hooks SB
Cellular signalling 2021 Jul;83:109974
Cellular signalling 2021 Jul;83:109974
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.
He X, Yang S, Deng J, Wu Q, Zang WJ
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):878-896
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):878-896
Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
Xu F, Zhu J, Chen Y, He K, Guo J, Bai S, Zhao R, Du J, Shen B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Feb;134:111126
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Feb;134:111126
Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis.
Hammad AS, Yu F, Botheju WS, Elmi A, Alcantara-Adap E, Machaca K
Cell calcium 2021 Dec;100:102496
Cell calcium 2021 Dec;100:102496
Mannan-binding lectin deficiency augments hepatic endoplasmic reticulum stress through IP3R-controlled calcium release.
Chen Y, Hu M, Deng F, Wang P, Lin J, Zheng Z, Liu Y, Dong L, Lu X, Chen Z, Zhou J, Zuo D
Cell calcium 2021 Dec;100:102477
Cell calcium 2021 Dec;100:102477
Soluble αKlotho downregulates Orai1-mediated store-operated Ca(2+) entry via PI3K-dependent signaling.
Kim JH, Park EY, Hwang KH, Park KS, Choi SJ, Cha SK
Pflugers Archiv : European journal of physiology 2021 Apr;473(4):647-658
Pflugers Archiv : European journal of physiology 2021 Apr;473(4):647-658
RANK promotes colorectal cancer migration and invasion by activating the Ca(2+)-calcineurin/NFATC1-ACP5 axis.
Liang Q, Wang Y, Lu Y, Zhu Q, Xie W, Tang N, Huang L, An T, Zhang D, Yan A, Liu S, Ye L, Zhu C
Cell death & disease 2021 Apr 1;12(4):336
Cell death & disease 2021 Apr 1;12(4):336
The role of Stim1 in the progression of lupus nephritis in mice.
Zhang F, Zhou X, Cui D, Zhang W, Lai J, Li X, Ruan Y, Xie Y, Shi M, Xiao Y, Wang Y, Zhou Y, Guo B
International journal of clinical and experimental pathology 2020;13(12):3021-3032
International journal of clinical and experimental pathology 2020;13(12):3021-3032
PD1 blockade enhances K(+) channel activity, Ca(2+) signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer.
Newton HS, Gawali VS, Chimote AA, Lehn MA, Palackdharry SM, Hinrichs BH, Jandarov R, Hildeman D, Janssen EM, Wise-Draper TM, Conforti L
Journal for immunotherapy of cancer 2020 Oct;8(2)
Journal for immunotherapy of cancer 2020 Oct;8(2)
STIM1-Ca(2+) signaling in coronary sinus cardiomyocytes contributes to interatrial conduction.
Zhang H, Bryson V, Luo N, Sun AY, Rosenberg P
Cell calcium 2020 May;87:102163
Cell calcium 2020 May;87:102163
Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry.
Togao M, Nakayama SMM, Ikenaka Y, Mizukawa H, Makino Y, Kubota A, Matsukawa T, Yokoyama K, Hirata T, Ishizuka M
Chemosphere 2020 Jan;238:124581
Chemosphere 2020 Jan;238:124581
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J
Cells 2020 Jan 9;9(1)
Cells 2020 Jan 9;9(1)
Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8(+) T cells of elderly mice.
Angenendt A, Steiner R, Knörck A, Schwär G, Konrad M, Krause E, Lis A
Aging 2020 Feb 12;12(4):3266-3286
Aging 2020 Feb 12;12(4):3266-3286
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Nitric Oxide Critically Regulates Purkinje Neuron Dendritic Development Through a Metabotropic Glutamate Receptor Type 1-Mediated Mechanism.
Tellios V, Maksoud MJE, Xiang YY, Lu WY
Cerebellum (London, England) 2020 Aug;19(4):510-526
Cerebellum (London, England) 2020 Aug;19(4):510-526
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, Zhao H, Ke J, Wu S, Wang X, Wu F
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
miRNA-dependent regulation of STIM1 expression in breast cancer.
Kulkarni RP, Elmi A, Alcantara-Adap E, Hubrack S, Nader N, Yu F, Dib M, Ramachandran V, Najafi Shoushtari H, Machaca K
Scientific reports 2019 Sep 10;9(1):13076
Scientific reports 2019 Sep 10;9(1):13076
Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis.
Yu F, Hubrack SZ, Chakraborty S, Sun L, Alcantara-Adap E, Kulkarni R, Billing AM, Graumann J, Taylor CW, Machaca K
Proceedings of the National Academy of Sciences of the United States of America 2019 May 21;116(21):10392-10401
Proceedings of the National Academy of Sciences of the United States of America 2019 May 21;116(21):10392-10401
FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis.
Wu L, Zhang D, Zhou L, Pei Y, Zhuang Y, Cui W, Chen J
EBioMedicine 2019 Mar;41:384-394
EBioMedicine 2019 Mar;41:384-394
E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca(2+) Store Replenishment.
Kang F, Zhou M, Huang X, Fan J, Wei L, Boulanger J, Liu Z, Salamero J, Liu Y, Chen L
Scientific reports 2019 Mar 8;9(1):3975
Scientific reports 2019 Mar 8;9(1):3975
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR 3rd, Shaw RJ
Cell reports 2019 Dec 3;29(10):3331-3348.e7
Cell reports 2019 Dec 3;29(10):3331-3348.e7
CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A.
Sharma A, Ramena G, Yin Y, Premkumar L, Elble RC
PloS one 2018;13(5):e0196512
PloS one 2018;13(5):e0196512
Inhibition of stromal-interacting molecule 1-mediated store-operated Ca(2+) entry as a novel strategy for the treatment of acquired imatinib-resistant gastrointestinal stromal tumors.
Yang Z, Pan L, Liu S, Li F, Lv W, Shu Y, Dong P
Cancer science 2018 Sep;109(9):2792-2800
Cancer science 2018 Sep;109(9):2792-2800
Profiling calcium signals of in vitro polarized human effector CD4(+) T cells.
Kircher S, Merino-Wong M, Niemeyer BA, Alansary D
Biochimica et biophysica acta. Molecular cell research 2018 Jun;1865(6):932-943
Biochimica et biophysica acta. Molecular cell research 2018 Jun;1865(6):932-943
STIM1 and STIM2 differently regulate endogenous Ca(2+) entry and promote TGF-β-induced EMT in breast cancer cells.
Zhang S, Miao Y, Zheng X, Gong Y, Zhang J, Zou F, Cai C
Biochemical and biophysical research communications 2017 Jun 17;488(1):74-80
Biochemical and biophysical research communications 2017 Jun 17;488(1):74-80
Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca(2+) entry regulates disassembly of adherens junctions.
Soni D, Regmi SC, Wang DM, DebRoy A, Zhao YY, Vogel SM, Malik AB, Tiruppathi C
American journal of physiology. Lung cellular and molecular physiology 2017 Jun 1;312(6):L1003-L1017
American journal of physiology. Lung cellular and molecular physiology 2017 Jun 1;312(6):L1003-L1017
Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells.
Shi J, Miralles F, Kinet JP, Birnbaumer L, Large WA, Albert AP
Channels (Austin, Tex.) 2017 Jul 4;11(4):329-339
Channels (Austin, Tex.) 2017 Jul 4;11(4):329-339
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Huang W, Ren C, Huang G, Liu J, Liu W, Wang L, Zhu B, Feng X, Shi J, Li J, Xia X, Jia W, Chen J, Chen Y, Jiang X
Oncology letters 2017 Feb;13(2):921-929
Oncology letters 2017 Feb;13(2):921-929
Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells.
Shi J, Miralles F, Birnbaumer L, Large WA, Albert AP
The Journal of physiology 2017 Feb 15;595(4):1039-1058
The Journal of physiology 2017 Feb 15;595(4):1039-1058
AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons.
Gruszczynska-Biegala J, Sladowska M, Kuznicki J
Frontiers in cellular neuroscience 2016;10:251
Frontiers in cellular neuroscience 2016;10:251
Expression profiling of human basophils: modulation by cytokines and secretagogues.
MacGlashan D Jr
PloS one 2015;10(5):e0126435
PloS one 2015;10(5):e0126435
STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
Zhang H, Sun AY, Kim JJ, Graham V, Finch EA, Nepliouev I, Zhao G, Li T, Lederer WJ, Stiber JA, Pitt GS, Bursac N, Rosenberg PB
Proceedings of the National Academy of Sciences of the United States of America 2015 Oct 13;112(41):E5618-27
Proceedings of the National Academy of Sciences of the United States of America 2015 Oct 13;112(41):E5618-27
Impairment of hepatic nuclear factor-4α binding to the Stim1 promoter contributes to high glucose-induced upregulation of STIM1 expression in glomerular mesangial cells.
Wang Y, Chaudhari S, Ren Y, Ma R
American journal of physiology. Renal physiology 2015 May 15;308(10):F1135-45
American journal of physiology. Renal physiology 2015 May 15;308(10):F1135-45
High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.
Chaudhari S, Wu P, Wang Y, Ding Y, Yuan J, Begg M, Ma R
American journal of physiology. Renal physiology 2014 May 1;306(9):F1069-80
American journal of physiology. Renal physiology 2014 May 1;306(9):F1069-80
Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin.
DebRoy A, Vogel SM, Soni D, Sundivakkam PC, Malik AB, Tiruppathi C
The Journal of biological chemistry 2014 Aug 29;289(35):24188-201
The Journal of biological chemistry 2014 Aug 29;289(35):24188-201
Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase.
Sundivakkam PC, Natarajan V, Malik AB, Tiruppathi C
The Journal of biological chemistry 2013 Jun 7;288(23):17030-17041
The Journal of biological chemistry 2013 Jun 7;288(23):17030-17041
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.
Hong JH, Li Q, Kim MS, Shin DM, Feske S, Birnbaumer L, Cheng KT, Ambudkar IS, Muallem S
Traffic (Copenhagen, Denmark) 2011 Feb;12(2):232-45
Traffic (Copenhagen, Denmark) 2011 Feb;12(2):232-45
Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons.
Gruszczynska-Biegala J, Pomorski P, Wisniewska MB, Kuznicki J
PloS one 2011 Apr 26;6(4):e19285
PloS one 2011 Apr 26;6(4):e19285
Functional interactions among STIM1, Orai1 and TRPC1 on the activation of SOCs in HL-7702 cells.
Zhang ZY, Pan LJ, Zhang ZM
Amino acids 2010 Jun;39(1):195-204
Amino acids 2010 Jun;39(1):195-204
Immunolocalization of STIM1 in the mouse brain.
Skibinska-Kijek A, Wisniewska MB, Gruszczynska-Biegala J, Methner A, Kuznicki J
Acta neurobiologiae experimentalis 2009;69(4):413-28
Acta neurobiologiae experimentalis 2009;69(4):413-28
Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease.
Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska-Kijek A, Gruszczynska-Biegala J, Kuznicki J
Biochimica et biophysica acta 2009 Jun;1793(6):1050-7
Biochimica et biophysica acta 2009 Jun;1793(6):1050-7
Expression of STIM1 in brain and puncta-like co-localization of STIM1 and ORAI1 upon depletion of Ca(2+) store in neurons.
Klejman ME, Gruszczynska-Biegala J, Skibinska-Kijek A, Wisniewska MB, Misztal K, Blazejczyk M, Bojarski L, Kuznicki J
Neurochemistry international 2009 Jan;54(1):49-55
Neurochemistry international 2009 Jan;54(1):49-55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11565-1-AP(STIM1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The STIM1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human STIM1. This antibody recognizes human, mouse antigen. The STIM1 antibody has been validated for the following applications: ELISA, WB, IP, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-STIM1 (IP:11565-1-AP, 3ug; Detection:11565-1-AP 1:1000) with Raji cells lysate 3800ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 11565-1-AP(STIM1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue