ALDH3A1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Description

Aldehyde dehydrogenase 3 family member A1

Tissue specificity

Tissue enhanced (esophagus, salivary gland, stomach)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (19737984 - 19748943)

Ensembl ID

ENSG00000108602  (ver. 103.38)

Orthologs

Mouse Aldh3a1: ENSMUSG00000019102

UniProt

P30838

neXtProt

NX_P30838

Human splice variants
Mouse splice variants

Protein structure