SPAG4

The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Description

Sperm associated antigen 4

Tissue specificity

Group enriched (pancreas, testis)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

20 (35615829 - 35621094)

Ensembl ID

ENSG00000061656  (ver. 103.38)

Orthologs

Mouse Spag4: ENSMUSG00000038180

UniProt

Q9NPE6

neXtProt

NX_Q9NPE6

Human splice variants
Mouse splice variants

Protein structure