318102

antibody from BioLegend

Targeting: HLA-DQB1 CELIAC1, HLA-DQB, IDDM1

Immunohistochemistry (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

318102

Provider

BioLegend

Product name

Purified anti-human HLA-DQ

Antibody type

Monoclonal

Antigen

HLA-DQ

Description

The HLADQ1 monoclonal antibody recognizes human HLA-DQ also known as MHC class II DQ monomorphic antigen. The major histocompatability complex is composed of two heterodimeric glycoproteins (α and β chains) with apparent molecular weights of 27 and 32 kD. In contrast to other MHC class II molecules, both polypeptide chains of HLA-DQ are polymorphic, with the α chain showing an extremely high degree of polymorphism. HLA-DQ is expressed on B cells in the peripheral blood, weakly on activated T cells and some monocytes. HLA-DQ is absent on hematopoietic progenitors, resting T cells, erythrocytes and platelets. HLA-DQ is expressed after HLA-DR and HLA-DP in hematopoietic development. HLA-DQ presents peptide fragments mainly from degraded intravesicular and extracellular proteins to CD4+ T lymphocytes. Specific alleles of HLA-DQ have been linked to the pathogenesis of several autoimmune diseases (including diabetes), both as a susceptibility and resistance factor depending on the particular polymorphism. The HLADQ1 antibody has been reported to be useful for flow cytometric detection of human HLA-DQ and immunohistochemistry (acetone-fixed frozen tissues and formalin-fixed paraffin-embedded tissues). The antibody HLADQ1 reacts with HLA-DQ 4,5,6,7,8,9 but does not react with DQ2, DR or DP.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.