Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- 318103 - Provider product page
- Provider
- BioLegend
- Product name
- FITC anti-human HLA-DQ
- Antibody type
- Monoclonal
- Antigen
- HLA-DQ
- Description
- The HLADQ1 monoclonal antibody recognizes human HLA-DQ also known as MHC class II DQ monomorphic antigen. The major histocompatability complex is composed of two heterodimeric glycoproteins (α and β chains) with apparent molecular weights of 27 and 32 kD. In contrast to other MHC class II molecules, both polypeptide chains of HLA-DQ are polymorphic, with the α chain showing an extremely high degree of polymorphism. HLA-DQ is expressed on B cells in the peripheral blood, weakly on activated T cells and some monocytes. HLA-DQ is absent on hematopoietic progenitors, resting T cells, erythrocytes and platelets. HLA-DQ is expressed after HLA-DR and HLA-DP in hematopoietic development. HLA-DQ presents peptide fragments mainly from degraded intravesicular and extracellular proteins to CD4+ T lymphocytes. Specific alleles of HLA-DQ have been linked to the pathogenesis of several autoimmune diseases (including diabetes), both as a susceptibility and resistance factor depending on the particular polymorphism. The HLADQ1 antibody has been reported to be useful for flow cytometric detection of human HLA-DQ and immunohistochemistry (acetone-fixed frozen tissues and formalin-fixed paraffin-embedded tissues).The antibody HLADQ1 reacts with HLA-DQ 4,5,6,7,8,9 but does not react with DQ2, DR or DP.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Herpes simplex virus antigens directly activate NK cells via TLR2, thus facilitating their presentation to CD4 T lymphocytes.
CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion.
Kim M, Osborne NR, Zeng W, Donaghy H, McKinnon K, Jackson DC, Cunningham AL
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4158-70
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4158-70
CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion.
Porter KA, Kelley LN, Nekorchuk MD, Jones JH, Hahn AB, de Noronha CM, Harton JA, Duus KM
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6480-8
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6480-8
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