10-3013-25

antibody from ABEOMICS Inc.
Targeting: TLR5 FLJ10052, MGC126430, MGC126431, SLEB1, TIL3
Provider product page for 10-3013-25

Antibody data

Product number
10-3013-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-TLR5 Antibody
Antibody type
Monoclonal
Description
Toll-like receptor 5 (TLR5) plays a fundamental role in pathogen recognition and downstream signaling to induce effective immunity. It is well expressed in major old tissues including lung, skin, intestine, and spleen. TLR5 is present in synovial of patients with rheumatoid arthritis (RA), act as novel mediator of innate immunity-induced osteoclastogenesis and bone loss. TLR5 is a receptor for flagellin and is present on the basolateral surface of intestinal epithelial cells. It is involved in the migration of intestinal epithelial cells through activation of the p38 MAPK pathway. TLR5-mediated signaling specifically enhanced the maturation of lung dendritic cells. TLR5 influences the progression and outcome of ovarian, sarcoma, and luminal breast tumors. Mutations in TLR5 have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant TLR5 p
rotein was used as the immunogen fo
r this antibody.
Isotype
IgG
Antibody clone number
ABM22G1
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
TLR5 protein structure - 10-3013-25 shown in red.